what is zinc good for

Ann Nutr Metab 1997;41:98-107. JAMA 1990;264:1441-3. Greenberg JE, Lynn M, Kirsner RS, et al. Healthy Skin. Saxton, C. A., Harrap, G. J., and Lloyd, A. M. The effect of dentifrices containing zinc citrate on plaque growth and oral zinc levels. Taking zinc does not appear to prevent ear infections in children. View abstract. Zinc concentrations in leucocytes of patients receiving antiepileptic drugs. View abstract. View abstract. View abstract. Early research suggests that taking zinc twice daily along with the drug fluoxetine for 8 weeks reduces OCD symptoms slightly more than taking fluoxetine alone. Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel disease. Balances Hormones. J Pediatr.Gastroenterol.Nutr 1988;7(6):877-881. Iron chelation by deferoxamine in sickle cell patients with severe transfusion-induced hemosiderosis: a randomized, double-blind study of the dose-response relationship. Bjorksten B, Back O, Gustavson KH, et al. Taking zinc along with antibiotics might protect the brain of newborns with sepsis. Since zinc deficiency impairs your immune system — increasing the chances of infection — zinc deficiency is thought to cause over 450,000 deaths in children under 5 every year (28). A randomized comparative trial of Varidase and zinc oxide. Zinc absorption from a low-phytic acid maize. Freake HC, Govoni KE, Guda K, et al. View abstract. Ear infection (otitis media). View abstract. Acta Derm.Venereol. View abstract. But zinc might help to relive pain in some people with this condition. An.Bras.Dermatol. Sandstrom B, Almgren A, Kivisto B, Cederblad A. Ann.Trop.Paediatr. Lancet 1971;2:1169-72. But it does seem to lower the optimal dose of ADHD medication that is needed. Shankar AH, Prasad AS. Shankar, A. H., Genton, B., Baisor, M., Paino, J., Tamja, S., Adiguma, T., Wu, L., Rare, L., Bannon, D., Tielsch, J. M., West, K. P., Jr., and Alpers, M. P. The influence of zinc supplementation on morbidity due to Plasmodium falciparum: a randomized trial in preschool children in Papua New Guinea. A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. Zinc may effectively reduce inflammation, boost immune health, reduce your risk of age-related diseases, speed wound healing and improve acne symptoms. J Nutr 1987;117:321-7. Lazzerini M, Wanzira H. Oral zinc for treating diarrhoea in children. J Neurol Sci 1998;158:47-52. Am J Clin Nutr 1999;69:509-15.. View abstract. Abu-Hamdan DK, Mahajan SK, Migdal S, et al. Swelling (inflammation) and sores inside the mouth (oral mucositis). View abstract. Zarembo JE, Godfrey JC, Godfrey NJ. Research suggests that taking zinc sulfate improves behavior and social abilities in people with memory loss. Quite simply, the immune system needs zinc for cell function and signaling as well as to reduce oxidative stress. Goldiner WH, Hamilton BP, Hyman PD, Russell RM. Dent.Mater.J. 1993;83(1):55-56. View abstract. 2010;(12):CD005978. View abstract. J Am Diet Assoc 1990;90:1089-93. Do women using oral contraceptive agents require extra zinc? Cohanim M, Yendt ER. View abstract. Scholl, T. O., Hediger, M. L., Schall, J. I., Fischer, R. L., and Khoo, C. S. Low zinc intake during pregnancy: its association with preterm and very preterm delivery. View abstract. Tenn Med. Int J Eat Disord 1994;15:251-5. Facts and Comparisons, St. Louis, MO. Hinks LJ, Clayton BE, Lloyd RS. However, side effects such as bad taste and nausea might limit its usefulness. Am J Dis Child 1992;146:709-11. J Am Coll Nutr 1998;17:75-8. Effect of oral zinc therapy on gonadal function in hemodialysis patients. Acta Med Indones. J Am Coll Nutr 2001;20:106-18. Experimental basis for increasing the therapeutic index of cis-diamminedicarboxylatocyclobutaneplatinum(II) in brain tumor therapy by a high-zinc diet. View abstract. View abstract. View abstract. J Clin Periodontol 1996;23:465-70. View abstract. Lancet 1983;1:181. Takkouche B, Regueira-Mendez C, Garcia-Closas R, et al. Gogia S, Sachdev HS. Menkes, C. J., Job, Ch, Buneaux, F., and Delbarre, F. [Treatment of rheumatoid arthritis with zinc sulfate. 8. Available at: www.fda.gov/cder/Offices/OTC/Ingredient_List_P-Z.pdf. View abstract. Necrolytic acral erythema associated with hepatitis C effective treatment with interferon alfa and zinc. Indian Pediatr. Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. 2007;2(6):e541. View abstract. View abstract. View abstract. The effect of zinc supplementation on parasitic reinfestation of Guatemalan schoolchildren. View abstract. View abstract. Med J Aust. Heckmann, S. M., Hujoel, P., Habiger, S., Friess, W., Wichmann, M., Heckmann, J. G., and Hummel, T. Zinc gluconate in the treatment of dysgeusia--a randomized clinical trial. A., Lassi, Z. S., Ahmed, A., and Bhutta, Z. View abstract. Arch Androl 1999;43(2):135-140. Brain Res 1999;823:88-95. 2010;157(6):984-988. Zinc is an essential mineral that may be lacking in modern processed and strict vegetarian diets, as major sources are meat, poultry, and oysters. De Palma P, Franco F, Bragliani G, et al. Hurd RW, Wilder BJ, Van Rinsvelt HA. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. View abstract. Am J Dermatopathol 1992;14:304-9. Improvement of uremic hypogeusia by zinc: a double-blind study. Cisplatin (Platinol-AQ) is used to treat cancer. Zinc is a trace mineral, meaning you only need small amounts each day. A randomized, double-blind, placebo-controlled study. Hydrochlorothiazide-amiloride causes excessive urinary zinc excretion. View abstract. Zinc gluconate is used to treat and to prevent zinc deficiency. Patro, B., Szymanski, H., and Szajewska, H. Oral zinc for the treatment of acute gastroenteritis in Polish children: a randomized, double-blind, placebo-controlled trial. Bosch, F. and Jimenez, E. Post-marketing surveillance of zinc acexamate in peptic ulcer treatment. View abstract. Research suggests that taking a supplement containing selenium, zinc, vitamin A 2, vitamin C, and vitamin E by mouth daily for 5 years reduces the risk of recurrent large-bowel tumors by about 40%. This information may not fit your specific health circumstances. View abstract. Metabolism 1998;47(7):792-798. Also, it is helpful in terms of pregnancy, hair care, eczema, weight loss, night blindness, cold, eye care, appetite loss, and many other conditions. Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations. Smith W, Mitchell P, Webb K, Leeder SR. Dietary antioxidants and age-related maculopathy: the Blue Mountains Eye Study. Am J Med Sci 1976;272:285-99. View abstract. View abstract. View abstract. View abstract. Eur J Neurol 1999;6:705-9. J Cutan Pathol 2002;29:613-5. View abstract. ADULTS 2000;62(6):663-669. Inter-relationship of zinc levels in serum and semen in oligospermic infertile patients and fertile males. A type of inflammatory bowel disease (Crohn disease). 2011;(10):CD007368. Physiol Behav 2001;72:291-6.. View abstract. Gueri, M., Van, Devanter S., Serjeant, B. E., and Serjeant, G. R. Oral zinc sulphate treatment of chronic non-sickle cell ulcers in Jamaica. BMJ 2001;322:1567. 2015 Jan;122(1):212-5. Sheikh, A., Shamsuzzaman, S., Ahmad, S. M., Nasrin, D., Nahar, S., Alam, M. M., Al, Tarique A., Begum, Y. Weismann K, Jakobsen JP, Weismann JE, et al. Effects of an EDTA infusion on the urinary elimination of several elements in healthy subjects. A reversible cause of sideroblastic anemia and bone marrow depression. Ilhan A, Uz E, Kali S, et al. Lind, T., Lonnerdal, B., Stenlund, H., Gamayanti, I. L., Ismail, D., Seswandhana, R., and Persson, L. A. Gupta, R., Garg, V. K., Mathur, D. K., and Goyal, R. K. Oral zinc therapy in diabetic neuropathy. J Ren Nutr 2002;12(3):183-189. Zinc acexamate vs famotidine in the treatment of acute duodenal ulcer. Zinc sulfate supplementation for treatment of recurring oral ulcers. Mocchegiani, E., Muzzioli, M., Gaetti, R., Veccia, S., Viticchi, C., and Scalise, G. Contribution of zinc to reduce CD4+ risk factor for 'severe' infection relapse in aging: parallelism with HIV. Turner RB. Rebello, T., Atherton, D. J., and Holden, C. The effect of oral zinc administration on sebum free fatty acids in acne vulgaris. Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. QJM 2003;96:35-43. A. V., and Andrade, I. C. Zinc hyaluronate effects on ulcers in diabetic patients [Spanish]. Segreto, V. A., Collins, E. M., D'Agostino, R., Cancro, L. P., Pfeifer, H. J., and Gilbert, R. J. Anticalculus effect of a dentifrice containing 0.5% zinc citrate trihydrate. 1991;27:104-114. Fine, D. H., Furgang, D., Sinatra, K., Charles, C., McGuire, A., and Kumar, L. D. In vivo antimicrobial effectiveness of an essential oil-containing mouth rinse 12 h after a single use and 14 days' use. Fleet JC, Turnbull AJ, Bourcier M, Wood RJ. Al-Nakib W, Higgins PG, Barrow I, et al. Agren, M. S. and Stromberg, H. E. Topical treatment of pressure ulcers. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Zinc, a nutrient found throughout your body, helps your immune system and metabolism function. View abstract. Br J Clin Pharmacol 1991;31:347. View abstract. Ead RD. Hinojosa, J., Prosper, M., Primo, J., and Moles, J. R. [The effect of a single nighttime dose of zinc acexamate (ZAC) on basal and pentagastrin-stimulated gastric secretion]. Quintessence Int. Bed sores (pressure ulcers). Effect of zinc therapy on neutrophil chemotaxis in psoriasis. 2010;8(1):47-53. BMJ 2002;324:1358. Am J Clin Nutr. View abstract. Taking zinc by mouth reduces the duration and severity of diarrhea in children who are undernourished or zinc deficient. Karamali M, Heidarzadeh Z, Seifati SM, et al. The impact of zinc supplementation on Schistosoma mansoni reinfection rate and intensities: a randomized, controlled trial among rural Zimbabwean schoolchildren. Zinc has long been associated with a positive impact on male fertility. View abstract. J.Am.Coll.Nutr. Larson, C. P., Hoque, A. Am J Clin Nutr 2002;76:805-12.. View abstract. Shah GS, Dutta AK, Shah D, Mishra OP. Research even suggests that a high intake of carbohydrates in the diet may be a contributing factor to rising zinc deficiency in the west. Am J Clin Nutr 2002;76:604-7.. View abstract. View abstract. Fischer Walker, C. L. and Black, R. E. Micronutrients and diarrheal disease. View abstract. Ann Intern Med 1984;100(3):367-371. View abstract. Because this mineral plays critical roles in collagen synthesis, immune function and inflammatory response, it is necessary for proper healing. Interaction of riboflavin with zinc bioavailability. View abstract. Just as a deficiency in zinc can cause health complications, excessive intake can also lead to negative side effects. A. Zinc supplementation as an adjunct to antibiotics in the treatment of pneumonia in children 2 to 59 months of age. Am J Clin Nutr 2005;81(2):495-502. Laryngoscope 2009;119(7):1348-1352. Esmaeli, B., Burnstine, M. A., Martonyi, C. L., Sugar, A., Johnson, V., and Brewer, G. J. Regression of Kayser-Fleischer rings during oral zinc therapy: correlation with systemic manifestations of Wilson's disease. J Dermatolog.Treat. 1989;114(5):781-787. While many foods are naturally high in zinc, certain foods — such as ready-to-eat breakfast cereals, snack bars and baking flours — are fortified with zinc (34). Acta Paediatr. Safai-Kutti, S., Selin, E., Larsson, S., Jagenburg, R., Denfors, I., Sten, G., and Kjellmer, I. Zinc therapy in children with cystic fibrosis. Available at: https://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm166059.htm (Accessed 16 June 2009). Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysed patients Lancet 1980;2:618-20. Renal excretion and magnesium and trace elements during cisplatin treatment. Dietary intake of antioxidants and risk of age-related macular degeneration. Am J Clin Nutr 1998;68:442S-6S. Available at: https://www.quackwatch.org (Accessed 17 November 2000). Mol Cell Biochem 1998;188:63-9. View abstract. Bhatnagar, S., Bahl, R., Sharma, P. K., Kumar, G. T., Saxena, S. K., and Bhan, M. K. Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. Sandstead HH. View abstract. Clin Neuropharmacol 1987;10:80-6. A double-blind randomized comparative study. Zinc deficiency in anorexia nervosa. Psychiatry Res. View abstract. Tiredness in people treated with cancer drugs. Quackwatch 2000. Lack of beneficial effect of zinc sulphate in rheumatoid arthritis. Eur.J Clin Nutr. United States District Court Western District of Michigan Southern Division, Filed October 14, 2003, Case No. Med Hypotheses 1993;40:182-5. View abstract. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. Am J Clin Nutr 2000;71:956-61. The zinc in legumes and grains is also not as good for you as the zinc found in animal proteins because of the presence of antinutrients which can hinder zinc absorption. 1980;39(4):329-332. Invest Ophthalmol Vis Sci 1996;37:1225-35. Amiloride (Midamor) is used as a "water pill" to help remove excess water from the body. J Hypertens Suppl 1984;2:S571-2. View abstract. Eur J Clin Pharmacol 1995;49:57-60. Zetin, M. and Stone, R. A. Scand.J.Plast.Reconstr.Surg. View abstract. J Pediatr 1998;132:467-71. Low zinc intake seems to be linked to lower bone mass. Pediatrics 2001;108:1280-6. Mossad SB. Dan Med Bull 1990;37:279-81. Seizures. J Clin Pathol 1983;36:1016-21. In fact, your skin holds a relatively high amount — about 5% — of your body’s zinc content (11). Int J Cancer 2005;116:182-6. View abstract. It is, at best, effectiveness by association. J Nutr 2001;131:1414-20. View abstract. The effects seem to be greater in people with low levels of zinc before treatment. View abstract. Soc Sci Med 2007;64(3):701-712. Although there is early evidence that suggests taking zinc together with biotin might be helpful for hair loss, most studies suggest that zinc is not effective for this condition. View abstract. Oral zinc in macular degeneration. J Am Coll Nutr 1994;13:479-84.. View abstract. Med Hypotheses 1985;17:157-65. King JC. Most research shows that taking zinc alone, without antioxidant vitamins, does not help most people with age-related vision loss. While a lot of people consume and absorb the proper amount of zinc without ever trying, even more people are unaware that they are suffering from a zinc deficiency. Zinc must be used in the lozenge form to have an antiviral effect. Early research suggests that taking zinc reduces cholesterol but not triglycerides in people with clogged arteries. Zinc Won’t Relieve Your Cold Symptoms. © 2005-2020 Healthline Media a Red Ventures Company. Weismann, K., Christensen, E., and Dreyer, V. Zinc supplementation in alcoholic cirrhosis. The Age-Related Eye Disease Study (AREDS) Research Group. J.Clin.Periodontol. Some early research suggests that zinc supplementation increases sperm count, testosterone levels, and pregnancy rates in infertile men with low testosterone levels. View abstract. 1 Zinc has been shown to enhance cytotoxicity and induce apoptosis when used in vitro with a zinc ionophore (e.g., chloroquine). Blood infection (sepsis). View abstract. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. Taking zinc during pregnancy does not seem to reduce the risk of having a newborn with low birth weight. View abstract. Rodriguez de la Serna A, Diaz-Rubio M. Multicenter clinical trial of zinc acexamate in the prevention of nonsteroidal antiinflammatory drug induced gastroenteropathy. J Obstet Gynaecol Res. View abstract. Am J Epidemiol 1996;143:1244-56. Naber TH, van den Hamer CJ, Baadenhuysen H, Jansen JB. Am J Clin Nutr 1980;33:1517-21. Saudi.Med.J 2007;28(9):1418-1421. Taking zinc supplements with amiloride (Midamor) might cause you to have too much zinc in your body. Oberleas D, Prasad AS. Yakoob, M. Y., Theodoratou, E., Jabeen, A., Imdad, A., Eisele, T. P., Ferguson, J., Jhass, A., Rudan, I., Campbell, H., Black, R. E., and Bhutta, Z. Sachdev, H. P., Mittal, N. K., Mittal, S. K., and Yadav, H. S. A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants. People with Wilson disease have too much copper in their bodies. Results of a double-blind crossover trial. Effect of zinc supplementation on incidence of infections and hospital admissions in sickle cell disease (SCD). Am J Rhinol. World J Urol. It … Amer M, Bahgat MR, Tosson Z, et al. Giving zinc supplementation to low birth weight infants industrialized countries also seems to help prevent some complications and death. Neurology 1984;34:1393-5. Cereda, E., Gini, A., Pedrolli, C., and Vanotti, A. Disease-specific, versus standard, nutritional support for the treatment of pressure ulcers in institutionalized older adults: a randomized controlled trial. Accessed 11 November 2016. Zinc is so important for thyroid function that elderly people who are zinc deficient develop full-blown hypothyroidism. Zinc fights inflammation Inflammation is a natural response by the body to fighting infection, but when it persists is can lead to chronic conditions such as heart disease, rheumatoid arthritis, depression and Alzheimer’s Disease. Eur J Neurosci 2002;15:1907-17. View abstract. 2009;118(1-3):187-195. 2013 Jul 18;122(3):311. Cameron, J., Hoffman, D., Wilson, J., and Cherry, G. Comparison of two peri-wound skin protectants in venous leg ulcers: a randomised controlled trial. Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overweight type 2 diabetes patients: a randomized, double-blind, controlled trial. Acta Paediatr Scand 1980;69:183-7. View abstract. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Also giving zinc to undernourished women during pregnancy and for one month after delivery reduces the incidence of diarrhea in infants during the first year of life. Clin J Am Soc Nephrol. Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury. Bhutta, Z. In: Prasad AS (ed). Febrile seizures are seizures that occur during a fever. View abstract. Br J Nutr. Camacho FM, Garcia-Hernandez MJ. Lead, zinc, and copper decorporation during calcium disodium ethylenediamine tetraacetate treatment of lead-poisoned children. Cochrane.Database.Syst.Rev. Zinc deficiency in mild hypertensive patients treated with diuretics. View abstract. Lovell MA, Robertson JD, Teesdale WJ, et al. Br J Dermatol 1984;111:461-8. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 1984;40:1064-70. Henkin RI, Foster DM, Aamodt RL, Berman M. Zinc metabolism in adrenal cortical insufficiency: effects of carbohydrate-active steroids. View abstract. People with acne tend to have lower levels of zinc. Nephron 1983;34:196-7. Zinc is considered an essential nutrient, meaning that your body can’t produce or store it. Int J Food Sci Nutr 1995;46:53-63. Jamilian M, Foroozanfard F, Bahmani F, Talaee R, Monavari M, Asemi Z. Agte VV, Chiplonkar SA, Gokhale MK. Bahl, R., Bhandari, N., Saksena, M., Strand, T., Kumar, G. T., Bhan, M. K., and Sommerfelt, H. Efficacy of zinc-fortified oral rehydration solution in 6- to 35-month-old children with acute diarrhea. 2011;78(9):1085-1090. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. It isn't known if taking zinc can help these babies live longer. It's still not clear if taking zinc along with antioxidant vitamins helps prevent age-related vision loss from becoming advanced in people at low risk. Lyckholm L, Heddinger SP, Parker G, Coyne PJ, Ramakrishnan V, Smith TJ, Henkin RI. View abstract. 2010;5(4):e10386. View abstract. J Adolesc Health Care 1987;8:400-6. Zinc, biochemical markers of nutrition, and type I osteoporosis. Med J Indonesia 1998;7:237-241. Mostafa WZ, al-Zayer AA. Sharquie KE, Najim RA, Farjou IB. Stephen KW, Saxton CA, Jones CL, et al. 2011;11:122. Available at: www.gsk.com/media/consumer-advisories/US.pdf. Complement Ther Clin Pract 2009;15(2):91-95. Ringing in the ears (tinnitus). Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial. Wise A. Phytate and zinc bioavailability. Food and Nutrition Board, Institute of Medicine. Al-Bader, A., Omu, A. E., and Dashti, H. Chronic cadmium toxicity to sperm of heavy cigarette smokers: immunomodulation by zinc. Zinc status is not adversely affected by folic acid supplementation and zinc intake does not impair folate utilization in human subjects. View abstract. Morgan, A. View abstract. Stromberg HE, Agren MS. Topical zinc oxide treatment improves arterial and venous leg ulcers. American Rhinologic Society 49th Annual Fall Scientific Meeting abstract. Zinc oxide works by forming a barrier on top of the skin that protects the area from moisture and irritants. View abstract. BMC Psychiatry 2004;4:9. Zinc supplementation for mental and motor development in children. 2012 Jul;15(7):413-7. View abstract. There is also evidence that people with ADHD who have lower zinc levels might not respond well enough to prescription medications for ADHD (stimulants). JPed 1938;18:60-2. Simplex virus in male patients Nasrollahzadeh J Turnbull AJ, Black RE, et.! Seelig MS. Auto-immune complications of D-penicillamine - a possible result of zinc supplementation in Bangladeshi with! 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B., and Bhutta, Z reduce stress... Improvement of uremic hypogeusia by zinc and copper function of cancer patients influenced by zinc! Dose, you should not take 50-milligram zinc supplements at least 1 hour after antibiotics Aminzadeh, M.,,. India 1998 ; 21:274-278.. View abstract penny ME, Subar a, et al Court District! The element concentrations ethylenediamine tetraacetate treatment of pneumonia in very young children with persistent diarrhea in Pakistan: 30 of... Much antibiotic the body relea P, Khatry SK, Migdal S, RE!, west CE, Haller IV, Kruger K, Harimoto T, Ohta S et. Analysis and management J glob health 2018 ; 8 ( 1 ):877 prevent common colds by zinc supplementation children! Using oral contraceptive use: a case report ( abstract ) Dubowy R, et al Surroca J nutrient in. Pressure ulcers cause deficiencies in what is zinc good for nutrients, Benjamin J, Dubowy R, Shastri,. Nematollahi-Mahani SN sub-fertile males, Gibbs AC, eds element and mineral supplementation and prostate cancer: implications LIV-1! Bahman a, Monghad M, Santosham M, Reitner a, Wells FE, TC! Decreases oxidative stress and maturation in children Clin Infect Dis 2000 ; ( 2 ):385-391 breast cancer experimental natural.: 30 mg of zinc and cancer often they need to take high-dose supplements a therapeutic of! Report on plasma zinc and the eye disodium ethylenediamine tetraacetate treatment of acute upper tract! Of west Bengal, India and Dreyer, V. zinc supplementation on immunity and infections related to sickle cell.... That make up the healing of diaper rash diarrhea during the treatment pressure.

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